Current COVID-19 vaccine studies

The CORONAVIT trial is a randomised controlled trial of 6200 people to evaluate the impact of vitamin D replacement on incidence and severity of acute respiratory infections, with a major focus on COVID-19. It is nested within the COVIDENCE UK study. All participants who were vaccinated during participation in the trial were offered anti-S antibody testing via dried blood spot; additionally a subset of 121 participants gave a venous blood sample post-vaccination for determination of neutralising antibody titres and antigen-specific T cell responses to SARS-CoV-2 peptides. These data will be analysed to determine whether vitamin D influences vaccine-induced host responses to SARS-CoV-2.