Current COVID-19 vaccine studies
The UK is a leading force in the development of vaccines for COVID-19. Search our database of studies and trials currently under way.
Individuals with antibody deficiency are prone to infectious diseases, respond poorly to existing vaccines and are particularly vulnerable to poor outcomes following SARS-CoV-2 infection.
COVID in patients with antibody deficiency (COV-AD) is a multi-site United Kingdom study that aims to:
i) determine the prevalence of asymptomatic and symptomatic SARS-CoV-2 infection in patients with primary and secondary antibody deficiency,
ii) determine how frequently SARS-CoV-2 viral persistence occurs in patients with primary and secondary antibody deficiency and
iii) characterise the immune response of these patients following SARS-CoV-2 infection and vaccination.
Study participants will be invited to submit a nasopharyngeal swab at study entry to determine asymptomatic/chronic viral carriage and serial swabs should the test positive during the course of the study which will be subject to viral sequencing. Antibody and T cell responses following infection and vaccination will be studied using ELISA and ELISPOT assays respectively. PBMCs will be stored for further detailed immunological analysis of vaccine responders and non-responders.
UK Research and Innovation