Evaluation of Risk Factors for Postbooster Omicron COVID-19 Deaths in England

With the emergence of the Omicron variant, it has become critical to identify risk factors associated with COVID-19 death in individuals who have completed primary vaccination and received a messenger RNA (mRNA) booster dose. Existing evidence is based on people who have received 1 or 2 doses of a COVID-19 vaccine and were infected by the Alpha or Delta variant. Understanding which groups are at increased risk of COVID-19 death after receiving a booster is crucial for the prioritization of further booster doses and access to COVID-19 therapeutics.

Author list



  1. Health Analysis and Life Events Division, Office for National Statistics, Newport, United Kingdom
  2. Department of Mathematics and Statistics, University of Strathclyde, Glasgow, United Kingdom
  3. Public Health Scotland, Glasgow, United Kingdom
  4. Usher Institute, University of Edinburgh, Edinburgh, United Kingdom


Vahé Nafilyan, PhD1; Isobel L. Ward, PhD1; Chris Robertson, PhD2,3; Aziz Sheikh, MD4; for the National Core Studies—Immunology Breakthrough Consortium

Novel Coronavirus SARS-CoV-2


Jana Network Open