Omicron neutralising antibodies after third COVID-19 vaccine dose in patients with cancer

Patients with cancer are at greater risk of severe COVID-19 and have been prioritised for COVID-19 vaccination globally. We previously showed that following two doses of COVID-19 vaccines, neutralising antibody (nAb) responses against the B.1.1.7 (alpha), B.1.351 (beta), and B.1.617.2 (delta) variants of concern (VOCs) are decreased compared to the wild type (WT) SARS-CoV-2, particularly in patients with blood cancer. More recently, we reported that following a third vaccine dose, nAb responses to these VOCs increase in most patients with cancer, including those with no or waning response following two vaccine doses. Since November, 2021, the B.1.1.529 (omicron) VOC has rapidly become the dominant SARS-CoV-2 VOC globally. Omicron partially evades vaccine-induced immunity, but a third vaccine dose increases omicron nAb responses in the general population. Comparable data in patients with cancer are lacking, leaving patients and cancer physicians without the means to calibrate infection risk while maintaining necessary cancer treatments. We used live-virus micro-neutralisation assays to evaluate response to omicron following three doses of COVID-19 vaccine in participants of the CAPTURE study (NCT03226886), a prospective, longitudinal cohort of patients with cancer.

Author list


Annika Fendler

Scott T C Shepherd

Lewis Au

Mary Wu

Ruth Harvey

Andreas M Schmitt

Zayd Tippu

Benjamin Shum

Sheima Farag

Aljosja Rogiers

Eleanor Carlyle

Kim Edmonds

Lyra Del Rosario

Karla Lingard

Mary Mangwende

Lucy Holt

Hamid Ahmod

Justine Korteweg

Tara Foley

Taja Barber

Andrea Emslie-Henry

Niamh Caulfield-Lynch

Fiona Byrne

Daqi Deng

Svend Kjaer

Ok-Ryul Song

Christophe Queval

Caitlin Kavanagh

Emma C Wall

Edward J Carr

Simon Caidan

Mike Gavrielides

James I MacRae

Gavin Kelly

Kema Peat

Denise Kelly

Aida Murra

Kayleigh Kelly

Molly O'Flaherty

Robyn L Shea

Gail Gardner

Darren Murray

Nadia Yousaf

Shaman Jhanji

Kate Tatham

David Cunningham

Nicholas Van As

Kate Young

Andrew J S Furness

Lisa Pickering

Rupert Beale

Charles Swanton

Sonia Gandhi

Steve Gamblin

David L V Bauer

George Kassiotis

Michael Howell

Emma Nicholson

Susanna Walker

James Larkin

Samra Turajlic

on behalf of theCAPTURE consortium


Novel Coronavirus SARS-CoV-2


The Lancet